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Nicotinamide Mononucleotide (NMN) powder is a bioactive nucleotide used as a precursor to NAD+, a vital coenzyme in energy metabolism and cellular repair. Promoted for anti-aging, cognitive enhancement, and metabolic support, it's typically taken as a dietary supplement for longevity benefits.

 

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Application • Reactant for parallel synthesis of dihydroisoquinolines via silver and L-proline co-catalyzed three-component coupling reaction • Reactant for chemoselective and regioselective preparation of benzoyl indoles • Reactant for preparation of novel PPARα/γ dual agonists for potential treatment of metabolic syndrome and IDDM • Reactant for preparation of 4,5-dihydrocyclopenta[c]quinolines by palladium-catalyzed ring-expansion reaction alkynes, using O2 as the oxidant • Reactant for preparation of vinylindoles by hydroarylation of alkynes using indium bromide catalyst • Reactant for gold catalyzed direct alkynylation using a benziodoxolone based hypervalent iodine reagent

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GS-441524, predominant metabolite of Remdesivir and superior to Remdesivir against Covid-19 , shows comparable efficacy in cell-based models of primary human lung and cat cells infected with coronavirus. GS-441524 could strongly inhibits feline infectious peritonitis virus (FIPV), with an EC50 of 0.78 μM The cells appear and grow normally at all concentrations of GS-441524 and fail to uptake the fluorescent dye CellTox Green at 24 h. The cytotoxic concentration-50% (CC50) is therefore>100 μM. The effective concentration-50% (EC50) of GS-441524 is calculated to be 0.78 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. All 10 treated cats have a rapid response to treatment and lymphocyte levels and rectal temperatures return to pre-infection levels and levels of the two asymptomatic cats. All ten of the once or twice treated cats have remained normal to date (more than eight months post infection). Injections cause a transient "stinging" reaction in some cats within 10 s of compound administration. Localized and transient pain is evidenced by unusual posturing, licking at the injection site and/or vocalizations that last for approximately 30-60 s after injection. Injection reactions are more pronounced in some animals relative to others and reactions are inconsistent from one injection to the next and decreas over time[1]. Remdesivi (IV injection) in NHP results in GS-441524 being present in serum at concentrations 1000-fold higher than Remdesivir throughout a 7-day treatment course. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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